Year Chemical Rank Pounds Num_Apps Acres 2021 SULFUR 1 40158469 120534 4732431 2021 MINERAL OIL 2 37089143 151244 4822049 2021 1,3-DICHLOROPROPENE 3 11086414 2807 61509 2021 POTASSIUM N-METHYLDITHIOCARBAMATE 4 8513080 2042 44736 2021 CHLOROPICRIN 5 8506588 2205 45991 2021 GLYPHOSATE, POTASSIUM SALT 6 5609918 80825 2783021 2021 GLYPHOSATE, ISOPROPYLAMINE SALT 7 4704007 72656 1916133 2021 CALCIUM HYDROXIDE 8 4331909 9202 206339 2021 METAM-SODIUM 9 3593891 499 17697 2021 SULFURYL FLUORIDE 10 3065098 47 42 2021 KAOLIN 11 2616436 2805 71882 2021 PENDIMETHALIN 12 2437026 30922 1114304 2021 METHYLATED SOYBEAN OIL* 13 2355756 128475 4171030 2021 COPPER HYDROXIDE 14 2044752 31739 997734 2021 PROPANIL 15 1968013 5809 413305 2021 GLUFOSINATE-AMMONIUM 16 1952176 68909 1920076 2021 ALPHA-(PARA-NONYLPHENYL)-OMEGA-HYDROXYPOLY(OXYETHYLENE)* 17 1818978 209253 8296943 2021 LIME-SULFUR 18 1679134 2976 103118 2021 METHYL BROMIDE 19 1603060 381 5785 2021 COPPER SULFATE (PENTAHYDRATE) 20 1381787 3052 181854 2021 SODIUM HYPOCHLORITE 21 1335028 111 2502 2021 COPPER ETHANOLAMINE COMPLEXES, MIXED 22 1329086 56 6542 2021 POTASSIUM PHOSPHITE 23 1259728 21829 418409 2021 MANCOZEB 24 1043342 28192 555543 2021 AMMONIUM SULFATE 25 1015194 70360 2423024 2021 CHLOROTHALONIL 26 913164 14323 406933 2021 COPPER SULFATE (BASIC) 27 883919 8821 224825 2021 OXYFLUORFEN 28 869732 62998 2028785 2021 BORIC ACID 29 725765 62 867 2021 LECITHIN* 30 710402 81839 2617080 2021 DIATOMACEOUS EARTH 31 695186 4909 42287 2021 OLEIC ACID, METHYL ESTER* 32 689657 15720 674247 2021 DISODIUM OCTABORATE TETRAHYDRATE 33 615180 44 4717 2021 METHOXYFENOZIDE 34 571255 36859 1951177 2021 HYDROGEN PEROXIDE 35 564514 14275 189893 2021 BURKHOLDERIA SP STRAIN A396 CELLS AND FERMENTATION MEDIA 36 527545 7899 88667 2021 ALPHA-UNDECYL-OMEGA-HYDROXYPOLY(OXYETHYLENE)* 37 488514 73643 2434053 2021 ZIRAM 38 487948 4855 88762 2021 HYDROGEN CYANAMIDE 39 478503 1107 33510 2021 VEGETABLE OIL* 40 449080 3657 322826 2021 PARAQUAT DICHLORIDE 41 426104 7719 399445 2021 BIFENTHRIN 42 425966 33547 1450253 2021 SODIUM BROMIDE 43 417695 0 194 2021 FATTY ACIDS, METHYL ESTERS 44 413156 8463 358639 2021 THIOBENCARB 45 394055 1377 116407 2021 4-NONYLPHENOL, FORMALDEHYDE RESIN, PROPOXYLATED* 46 376647 36697 1130188 2021 FATTY ACIDS, C16-C18 AND C18-UNSATURATED, METHYL ESTERS* 47 359969 31742 933661 2021 BENSULIDE 48 340608 9736 93386 2021 CAPTAN 49 332842 5844 190677 2021 IMIDACLOPRID 50 330638 48480 1070291 2021 2,4-D, DIMETHYLAMINE SALT 51 330382 7114 268137 2021 ETHEPHON 52 317821 8984 381836 2021 BIFENAZATE 53 315776 12255 495356 2021 COPPER OXYCHLORIDE 54 310974 9132 271077 2021 TRIFLURALIN 55 304787 6685 261165 2021 SULFUR DIOXIDE 56 295852 175 129 2021 S-METOLACHLOR 57 291451 4547 192514 2021 PEROXYACETIC ACID 58 289683 13388 189103 2021 CRYOLITE 59 288310 1343 34714 2021 OLEIC ACID, ETHYL ESTER* 60 284148 27653 577747 2021 CAPRYLIC ACID 61 271317 2916 41044 2021 SODIUM CARBONATE PEROXYHYDRATE 62 266624 207 12227 2021 CASTOR OIL ETHOXYLATE* 63 255260 7655 243917 2021 AZOXYSTROBIN 64 252486 31578 1266941 2021 PETROLEUM OIL, UNCLASSIFIED 65 252249 439 18310 2021 SODIUM CHLORITE 66 251911 143 8328 2021 MALATHION 67 247106 8612 157033 2021 METHYLATED FATTY ACIDS FROM CANOLA OIL* 68 245001 3964 156757 2021 BORAX 69 241002 469 17410 2021 METHOMYL 70 235742 22687 368623 2021 DIETHYLENE GLYCOL* 71 231261 26508 1375352 2021 COPPER OXIDE (OUS) 72 220425 4290 82059 2021 BACILLUS AMYLOLIQUEFACIENS STRAIN D747 73 220056 5983 54626 2021 DIMETHYLPOLYSILOXANE* 74 205880 134989 4899422 2021 PERMETHRIN 75 203283 36107 504184 2021 SODIUM CHLORATE 76 199114 355 22381 2021 CHLORANTRANILIPROLE 77 198752 47880 2323295 2021 NALED 78 194516 4044 136832 2021 BUPROFEZIN 79 194087 5047 207259 2021 CHLORTHAL-DIMETHYL 80 193533 6193 47207 2021 CAPRIC ACID 81 192755 2914 41017 2021 POTASSIUM BICARBONATE 82 192488 5403 72168 2021 PHOSPHORIC ACID 83 192143 58455 1900125 2021 CITRIC ACID 84 191635 62948 2185354 2021 GLYPHOSATE, DIMETHYLAMINE SALT 85 190622 1630 53811 2021 ALPHA-PINENE BETA-PINENE COPOLYMER* 86 189361 25546 669646 2021 TRICLOPYR, TRIETHYLAMINE SALT 87 185789 4189 294920 2021 UREA DIHYDROGEN SULFATE 88 185288 11645 469740 2021 PROPIONIC ACID 89 184964 37986 1091157 2021 CHLORINE 90 180763 0 None 2021 CORN STEEP LIQUOR* 91 175174 1200 45126 2021 CLETHODIM 92 174040 25980 1062714 2021 LAMBDA-CYHALOTHRIN 93 173094 70450 2473490 2021 POTASH SOAP 94 169318 8699 34820 2021 TALL OIL FATTY ACIDS* 95 168605 47630 1773987 2021 EMULSIFIABLE METHYLATED VEGETABLE OIL* 96 168160 18885 333952 2021 ALPHA-(PARA-NONYLPHENYL)-OMEGA-HYDROXYPOLY(OXYETHYLENE), PHOSPHATE ESTER* 97 163697 29481 1030472 2021 PROPYLENE OXIDE 98 163231 0 None 2021 FATTY ACIDS, MIXED* 99 163055 41048 1807121 2021 ALKYL(42\%C12, 26\%C18, 15\%C14, 8\%C16, 5\%C10, 4\%C8)1,3-PROPYLENEDIAMINE 100 161578 0 3